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AWL-II-38.3 is a potent ephrin-A receptor (EphA3) kinase inhibitor. AWL-II-38.3 does not exhibit significant cellular activity against Src-family kinases nor against b-raf .
Antimalarial agent 36 (compound 1) is an antimalarial agent, with the EC50s of 58 nM and 42 nM, for Dd2 and 3D7, respectively. Antimalarial agent 36 targets EphA2 .
Angiogenesis is the physiological process through which new blood vessels are formed from pre-existing vessels. It occurs in various physiological processes e.g. embryonic development, menstrual cycle, exercise and wound healing etc. Angiogenesis is regulated by both endogenous activators and inhibitors. Some key activators of angiogenesis include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), angiogenin, TGF-β, etc. whereas angiogenesis inhibitors are angiostatin, endostatin, interferon, platelet factor 4, etc. The loss of balance between these opposing signals leads to life threatening diseases like cancer, cardiovascular and ischemic diseases etc. which are thus controlled by exogenous angiogenesis activators (for cardiovascular/ischemic disorders) and inhibitors (for cancer).
MCE offers a unique collection of 1984 compounds with validated angiogenesis targets modulating properties. MCE angiogenesis-related compound library is an effective tool for angiogenesis research and discovery of angiogenesis-related drugs.
EphB2 Protein is a neurotrophic factor, and a member of the eph receptor tyrosine kinase. EphB2 plays an important role in cancer progression and in immunity. EphB2 can bind to directly to the NMDA receptor and induces its tyrosine phosphorylation. EphB2 is essential for neuronal connectivity and plasticity in the brain, as well as synaptic function. Besides, EphB2 can also interact with cells expressing ephrinB ligands, and results in EphB2 activation and phosphorylation of tyrosines in the ephrinB cytodomain. EphB2 also regulates thrombus formation and clot retraction. EphB2 Protein, Human (HEK293, Fc) is the recombinant human-derived EphB2 protein, expressed by HEK293, with C-hFc labeled tag. The total length of EphB2 Protein, Human (HEK293, Fc) is 464 a.a., with molecular weight of 95-120 kDa.
The EphA7 protein is a receptor tyrosine kinase that participates in bidirectional signaling with GPI-anchored ephrin-A ligands (especially EFNA5). It affects brain development by regulating intercellular adhesion and repulsion, contributing to axonal guidance of corticothalamic and retinal axons. EphA7 Protein, Mouse (HEK293, His) is the recombinant mouse-derived EphA7 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphA7 Protein, Mouse (HEK293, His) is 529 a.a., with molecular weight of 68-77 kDa.
EphB6, a kinase-defective receptor, interacts with ephrin-B1 and ephrin-B2, regulating cell adhesion and migration. It inhibits JNK activation, reduces IL-2 secretion and CD25 expression in response to ephrin-B2. EphB6 interacts with CBL, EPHB1, and FYN, highlighting its multifaceted role in cellular signaling. EphB6 Protein, Human (HEK293) is the recombinant human-derived EphB6 protein, expressed by HEK293 , with tag free. The total length of EphB6 Protein, Human (HEK293) is 563 a.a., with molecular weight of ~72 kDa.
The EphB3 protein is a receptor tyrosine kinase that binds to the transmembrane ephrin B ligand to initiate bidirectional signaling. The forward signal originates from the receptor, while the reverse signal originates from the ephrin ligand. EphB3 Protein, Rat (HEK293, His) is the recombinant rat-derived EphB3 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphB3 Protein, Rat (HEK293, His) is 508 a.a., with molecular weight of ~60-70 kDa.
EphB6, a kinase-defective receptor, interacts with ephrin-B1 and ephrin-B2, regulating cell adhesion and migration. It inhibits JNK activation, reduces IL-2 secretion and CD25 expression in response to ephrin-B2. EphB6 interacts with CBL, EPHB1, and FYN, highlighting its multifaceted role in cellular signaling. EphB6 Protein, Human (HEK293, Fc) is the recombinant human-derived EphB6 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EphB6 Protein, Human (HEK293, Fc) is 563 a.a., with molecular weight of 100-110 kDa.
EphB6, a kinase-defective receptor, interacts with ephrin-B1 and ephrin-B2, regulating cell adhesion and migration. It inhibits JNK activation, reduces IL-2 secretion and CD25 expression in response to ephrin-B2. EphB6 interacts with CBL, EPHB1, and FYN, highlighting its multifaceted role in cellular signaling. EphB6 Protein, Human (HEK293, His) is the recombinant human-derived EphB6 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphB6 Protein, Human (HEK293, His) is 563 a.a., with molecular weight of 60-70 kDa.
EphB6 Protein, a kinase-defective receptor, binds ephrin-B1 and ephrin-B2, influencing cell adhesion and migration with nuanced effects. Its interaction with ephrin-B2 inhibits JNK activation, T-cell receptor-induced IL-2 secretion, and CD25 expression. EphB6 also interacts with CBL, EPHB1, and ligand-independently with FYN, highlighting its intricate role in cellular signaling pathways. EphB6 Protein, Mouse (HEK293, His) is the recombinant mouse-derived EphB6 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphB6 Protein, Mouse (HEK293, His) is 555 a.a., with molecular weight of ~66 kDa.
EphB6 is a member of the receptor tyrosine kinase family expressed primarily in thymic cells and T cell subpopulations. EphB6, when stimulated by ephrin-B2, inhibited JNK activation, and decreased T-cell receptor-induced IL-2 secretion and CD25 expression. EphB6 promotes colorectal epithelial cell transformation and may serve as a novel biomarker and therapeutic target for colorectal cancer. EphB6 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived EphB6 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EphB6 Protein, Cynomolgus (HEK293, Fc) is 559 a.a., with molecular weight of 90-110 kDa.
EphB4 protein is a receptor tyrosine kinase that binds to ephrin B ligand and initiates bidirectional signaling. Positive signaling regulates the rejection and separation of cells from EFNB2-expressing cells. EphB4 Protein, Human (HEK293) is the recombinant human-derived EphB4 protein, expressed by HEK293 , with tag free. The total length of EphB4 Protein, Human (HEK293) is 539 a.a., with molecular weight of 65-70 kDa.
EphA2 protein is a receptor tyrosine kinase that promiscuously binds to ephrin A ligands to initiate bidirectional signaling. EphA2 is activated by ephrin-A1/EFNA1, regulates cell migration, adhesion, proliferation and differentiation, modulates DSG1 and inhibits ERK1/ERK2 signaling. EphA2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived EphA2 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphA2 Protein, Mouse (HEK293, His) is 510 a.a., with molecular weight of ~65-95 kDa.
Ephrin B3 Protein, a member of the ephrin family, lacks conserved residue(s) crucial for feature annotation propagation. This unique molecular profile suggests distinct functional properties and interactions within the ephrin family. Investigating the specific role and implications of this divergence in conserved residues is crucial to understand Ephrin B3's functional nuances and cellular significance in biological processes. Ephrin B3 Protein, Rat (HEK293, Fc) is the recombinant rat-derived Ephrin B3 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Ephrin B3 Protein, Rat (HEK293, Fc) is 224 a.a., with molecular weight of ~55 & 34 kDa, respectively.
Ephrin B3 Protein, a member of the ephrin family, lacks conserved residue(s) crucial for feature annotation propagation. This unique molecular profile suggests distinct functional properties and interactions within the ephrin family. Investigating the specific role and implications of this divergence in conserved residues is crucial to understand Ephrin B3's functional nuances and cellular significance in biological processes. Ephrin B3 Protein, Rat (HEK293, His) is the recombinant rat-derived Ephrin B3 protein, expressed by HEK293 , with C-His labeled tag. The total length of Ephrin B3 Protein, Rat (HEK293, His) is 197 a.a., with molecular weight of 27-32 kDa.
EphA2 protein is a receptor tyrosine kinase that participates in bidirectional signaling with various ephrin A ligands, affecting cell migration, adhesion, proliferation and differentiation. It regulates cell adhesion and differentiation by interacting with DSG1 and inhibiting the ERK1/ERK2 signaling pathway. EphA2 Protein, Human (sf9, His-GST) is the recombinant human-derived EphA2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of EphA2 Protein, Human (sf9, His-GST) is 392 a.a., with molecular weight of ~62 kDa.
Ephb4 Protein, a receptor tyrosine kinase, plays a critical role in angiogenesis and development. Dysregulation of Ephb4 Protein has been associated with disorders like cancer and cardiovascular diseases. Targeting Ephb4 Protein may provide potential therapeutic interventions in these conditions by modulating angiogenesis, inhibiting tumor growth, and managing cardiovascular complications. EphB4 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived EphB4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EphB4 Protein, Mouse (HEK293, Fc) is 539 a.a., with molecular weight of ~110 kDa.
Ephb4 Protein, a receptor tyrosine kinase, plays a critical role in angiogenesis and development. Dysregulation of Ephb4 Protein has been associated with disorders like cancer and cardiovascular diseases. Targeting Ephb4 Protein may provide potential therapeutic interventions in these conditions by modulating angiogenesis, inhibiting tumor growth, and managing cardiovascular complications. EphB4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived EphB4 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphB4 Protein, Mouse (HEK293, His) is 524 a.a., with molecular weight of ~75 kDa.
EphB4 protein is a receptor tyrosine kinase that binds to ephrin B ligand and initiates bidirectional signaling. Positive signaling regulates the rejection and separation of cells from EFNB2-expressing cells. EphB4 Protein, Human (HEK293, Fc) is the recombinant human-derived EphB4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EphB4 Protein, Human (HEK293, Fc) is 539 a.a., with molecular weight of 105-115 kDa.
EphA2 Protein, a receptor tyrosine kinase, engages in bidirectional signaling with ephrin-A ligands, influencing migration, adhesion, proliferation, and differentiation. EphA2 interacts with DSG1, inhibiting ERK1/ERK2 signaling, impacting cell adhesion and UV radiation-induced apoptosis. In development, EphA2 contributes to pattern formation, angiogenesis, hindbrain development, and mammary gland morphogenesis. Its interaction with Ephrin-A5 maintains lens transparency, and in bone remodeling, it regulates osteoclastogenesis and osteoblastogenesis through Ephrin-A2 interaction. EphA2 also acts as a receptor for hepatitis C virus in hepatocytes, facilitating viral entry and membrane fusion. EphA2 Protein, Cynomolgus (HEK293, hFc) is the recombinant cynomolgus-derived EphA2 protein, expressed by HEK293, with C-hFc labeled tag. The total length of EphA2 Protein, Cynomolgus (HEK293, hFc) is 511 a.a., with molecular weight of 90-100 kDa.
Ephrin B3 protein, a transmembrane ligand, binds adjacent Eph receptors, triggering bidirectional signaling. It induces axon collapse in vitro and may influence axon guidance and orientation. Ephrin B3 interacts with GRIP1 and GRIP2, suggesting regulatory roles in development and cellular functions. Ephrin B3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Ephrin B3 protein, expressed by HEK293 , with C-His labeled tag. The total length of Ephrin B3 Protein, Mouse (HEK293, His) is 200 a.a., with molecular weight of ~23.5 kDa.
Ephrin B3 protein, a transmembrane ligand, binds adjacent Eph receptors, triggering bidirectional signaling. It induces axon collapse in vitro and may influence axon guidance and orientation. Ephrin B3 interacts with GRIP1 and GRIP2, suggesting regulatory roles in development and cellular functions. Ephrin B3 Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived Ephrin B3 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Ephrin B3 Protein, Mouse (HEK293, hFc) is 227 a.a., with molecular weight of ~48.8 kDa.
The EphA2 protein is an important member of the ephrin receptor subfamily that mediates developmental events, particularly in the nervous system. It has a single kinase domain and an extracellular region that binds ephrin-A ligands. EphA2 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived EphA2 protein, expressed by HEK293 , with C-6*His, C-Avi labeled tag. The total length of EphA2 Protein, Human (Biotinylated, HEK293, His-Avi) is 511 a.a., with molecular weight of ~59.4 kDa.
EphB4 protein is a receptor tyrosine kinase that binds to ephrin B ligand and initiates bidirectional signaling. Positive signaling regulates the rejection and separation of cells from EFNB2-expressing cells. EphB4 Protein, Human (sf9, His-GST) is the recombinant human-derived EphB4 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of EphB4 Protein, Human (sf9, His-GST) is 425 a.a., with molecular weight of ~66 kDa.
The EphA1 protein is a receptor tyrosine kinase that promiscuously binds to ephrin-A ligands on neighboring cells, initiating contact-dependent bidirectional signaling. The forward signal originates from the receptor and the reverse signal originates from the ephrin ligand. EphA1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived EphA1 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphA1 Protein, Mouse (HEK293, His) is 522 a.a., with molecular weight of ~68 kDa.
EphA1 Protein, a receptor tyrosine kinase, engages in bidirectional signaling with membrane-bound ephrin-A ligands. Activation by EFNA1 regulates cell attachment, motility, angiogenesis, and proliferation. EphA1 may also play a role in apoptosis. EphA1 Protein, Human (HEK293, hFc) is the recombinant human-derived EphA1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EphA1 Protein, Human (HEK293, hFc) is 547 a.a., with molecular weight of ~83.3 kDa.
EphB4 protein is a receptor tyrosine kinase that binds to ephrin B ligand and initiates bidirectional signaling. Positive signaling regulates the rejection and separation of cells from EFNB2-expressing cells. EphB4 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived EphB4 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphB4 Protein, Human (Biotinylated, HEK293, His) is 539 a.a., with molecular weight of ~58.5 KDa.
EphA2 Protein, a receptor tyrosine kinase, engages in bidirectional signaling with ephrin-A ligands, influencing migration, adhesion, proliferation, and differentiation. EphA2 interacts with DSG1, inhibiting ERK1/ERK2 signaling, impacting cell adhesion and UV radiation-induced apoptosis. In development, EphA2 contributes to pattern formation, angiogenesis, hindbrain development, and mammary gland morphogenesis. Its interaction with Ephrin-A5 maintains lens transparency, and in bone remodeling, it regulates osteoclastogenesis and osteoblastogenesis through Ephrin-A2 interaction. EphA2 also acts as a receptor for hepatitis C virus in hepatocytes, facilitating viral entry and membrane fusion. EphA2 Protein, Cynomolgus (HEK293, His-Avi) is the recombinant cynomolgus-derived EphA2 protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of EphA2 Protein, Cynomolgus (HEK293, His-Avi) is 511 a.a., with molecular weight of 60-70 kDa.
The EphB3 protein is a receptor tyrosine kinase that binds to the transmembrane ephrin B ligand to initiate bidirectional signaling. The forward signal originates from the receptor, while the reverse signal originates from the ephrin ligand. EphB3 Protein, Mouse (537a.a, HEK293, His) is the recombinant mouse-derived EphB3 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphB3 Protein, Mouse (537a.a, HEK293, His) is 537 a.a., with molecular weight of ~63 kDa.
Ephrin-A5/EFNA5 Protein is a member of the ephrin family of proteins, which are transmembrane proteins that act as both ligands and receptors. It interacts with Eph receptors on adjacent cells through bidirectional signaling, which triggers a series of intracellular events that regulate various cellular processes, including cell adhesion, repulsion, and migration. Ephrin-A5/EFNA5 Protein plays a crucial role in the development of neurons, blood vessels, epithelia, embryonic development, and fertility. Ephrin A5 Protein, Canine (HEK293, Fc) is the recombinant canine-derived Ephrin A5 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Ephrin A5 Protein, Canine (HEK293, Fc) is 183 a.a., with molecular weight of ~59 kDa.
EphA2 protein is a receptor tyrosine kinase that participates in bidirectional signaling with various ephrin A ligands, affecting cell migration, adhesion, proliferation and differentiation. It regulates cell adhesion and differentiation by interacting with DSG1 and inhibiting the ERK1/ERK2 signaling pathway. EphA2 Protein, Human (HEK293, His) is the recombinant human-derived EphA2 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphA2 Protein, Human (HEK293, His) is 511 a.a., with molecular weight of 65-75 kDa.
EphA6 Protein, a receptor tyrosine kinase, engages in promiscuous binding with GPI-anchored ephrin-A ligands, facilitating contact-dependent bidirectional signaling. EphA6 mediates intricate signaling exchanges between cells, playing a crucial role in diverse cellular processes through both forward and reverse signaling pathways. EphA6 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived EphA6 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EphA6 Protein, Mouse (HEK293, Fc) is 546 a.a., with molecular weight of ~110 kDa.
EphA6 Protein, a receptor tyrosine kinase, engages in promiscuous binding with GPI-anchored ephrin-A ligands, facilitating contact-dependent bidirectional signaling. EphA6 mediates intricate signaling exchanges between cells, playing a crucial role in diverse cellular processes through both forward and reverse signaling pathways. EphA6 Protein, Mouse (HEK293, His) is the recombinant mouse-derived EphA6 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphA6 Protein, Mouse (HEK293, His) is 524 a.a., with molecular weight of ~65-70 kDa.
EphB1 protein is a receptor tyrosine kinase that participates in bidirectional signaling with ephrin B ligands (including EFNB1, EFNB2, and EFNB3). It plays a crucial role in retinal axon guidance, neural progenitor cell regulation, dendritic spine maturation, synapse formation, angiogenesis, targeted cell migration, and muscle stem cell maintenance. EphB1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived EphB1 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphB1 Protein, Mouse (HEK293, His) is 522 a.a., with molecular weight of ~65-75 kDa.
Ephrin-A5/EFNA5 Protein, a cell surface GPI-bound ligand, crucially interacts with Eph receptors, inducing bidirectional signaling and regulating adhesion, organization, and development in neurons, vasculature, and epithelium. It forms complexes with EPHA3, EPHA8, and ADAM10, impacting internalization and function, while also mediating communication in pancreatic islet cells and influencing brain development. Ephrin-A5/EFNA5 Protein, Human (HEK293, His) is the recombinant human-derived Ephrin-A5/EFNA5 protein, expressed by HEK293 , with C-His labeled tag. The total length of Ephrin-A5/EFNA5 Protein, Human (HEK293, His) is 183 a.a., with molecular weight of ~27 kDa.
The Ephrin-A5/EFNA5 protein is an important cell surface ligand that plays an important role in neuronal, vascular, and epithelial development. It binds to Eph receptors, initiating bidirectional signaling and regulating intercellular adhesion, cytoskeletal organization, and lens transparency. Ephrin-A5/EFNA5 Protein, Rat (HEK293, Fc) is the recombinant rat-derived Ephrin-A5/EFNA5 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Ephrin-A5/EFNA5 Protein, Rat (HEK293, Fc) is 182 a.a., with molecular weight of ~55 kDa.
The Ephrin-A5/EFNA5 protein is an important cell surface ligand that plays an important role in neuronal, vascular, and epithelial development. It binds to Eph receptors, initiating bidirectional signaling and regulating intercellular adhesion, cytoskeletal organization, and lens transparency. Ephrin-A5/EFNA5 Protein, Rat (HEK293, His) is the recombinant rat-derived Ephrin-A5/EFNA5 protein, expressed by HEK293 , with C-His labeled tag. The total length of Ephrin-A5/EFNA5 Protein, Rat (HEK293, His) is 182 a.a., with molecular weight of ~27 kDa.
Ephrin-A5/EFNA5 protein is the GPI-binding ligand of Eph receptor and plays a crucial role in neuronal, vascular and epithelial development. It binds to nearby Eph receptors, initiating bidirectional signaling and regulating intercellular adhesion and cytoskeletal organization. Ephrin-A5/EFNA5 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Ephrin-A5/EFNA5 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Ephrin-A5/EFNA5 Protein, Mouse (HEK293, Fc) is 183 a.a., with molecular weight of ~52 kDa.
Ephrin-A5 (EFNA5) is a member of the ephrin family. Ephrin-A5/EFNA5 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived Ephrin-A5/EFNA5 protein, expressed by HEK293, with C-hFc labeled tag. The total length of Ephrin-A5/EFNA5 Protein, Rhesus Macaque (HEK293, Fc) is 183 a.a., with molecular weight of ~48.2 KDa.
Ephrin-A5 (EFNA5) is a member of the ephrin family. Ephrin-A5/EFNA5 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived Ephrin-A5/EFNA5 protein, expressed by HEK293, with C-His labeled tag. The total length of Ephrin-A5/EFNA5 Protein, Rhesus Macaque (HEK293, His) is 183 a.a., with molecular weight of ~27 KDa.
The EphB1 protein is a receptor tyrosine kinase that promiscuously binds to the transmembrane ephrin-B ligand of adjacent cells, initiating bidirectional signaling. The forward signal originates from the receptor and the reverse signal originates from the ephrin ligand. EphB1 Protein, Human (sf9, His-GST) is the recombinant human-derived EphB1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of EphB1 Protein, Human (sf9, His-GST) is 420 a.a., with molecular weight of ~66 kDa.
EphB1 protein is a receptor tyrosine kinase that participates in bidirectional signaling with ephrin B ligands (including EFNB1, EFNB2, and EFNB3). It plays a crucial role in retinal axon guidance, neural progenitor cell regulation, dendritic spine maturation, synapse formation, angiogenesis, targeted cell migration, and muscle stem cell maintenance. EphB1 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived EphB1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of EphB1 Protein, Mouse (sf9, His-GST) is 394 a.a., with molecular weight of ~60 kDa.
EphB1, a tyrosine kinase receptor, was promiscuously bound to the transmembrane ligand ephrin-B family on adjacent cells, initiating contact-dependent bidirectional signaling. EphB1 activates the MAPK/ERK and JNK signaling cascades that regulate cell migration and adhesion, respectively. EphB1 promotes differentiation and maturation of dendritic cells in non-small cell lung cancer. EphB1 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived EphB1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EphB1 Protein, Rhesus Macaque (HEK293, Fc) is 540 a.a., with molecular weight of ~85.4 KDa.
EphB1, a tyrosine kinase receptor, was promiscuously bound to the transmembrane ligand ephrin-B family on adjacent cells, initiating contact-dependent bidirectional signaling. EphB1 activates the MAPK/ERK and JNK signaling cascades that regulate cell migration and adhesion, respectively. EphB1 promotes differentiation and maturation of dendritic cells in non-small cell lung cancer. EphB1 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived EphB1 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphB1 Protein, Rhesus Macaque (HEK293, His) is 523 a.a., with molecular weight of ~59.9 KDa.
The EphB2 protein is a receptor tyrosine kinase that binds to the transmembrane ephrin B ligand on adjacent cells to initiate bidirectional signaling. The forward signal originates from the receptor, while the reverse signal originates from the ephrin ligand. EphB2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived EphB2 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphB2 Protein, Mouse (HEK293, His) is 540 a.a., with molecular weight of ~65 kDa.
EphB2 protein is a member of the Eph receptor family and has a ligand-binding domain, a transmembrane region, and an intracellular kinase domain. It preferentially binds ephrin-B ligands and plays a role in nervous system and vascular development. EphB2 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived EphB2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EphB2 Protein, Mouse (HEK293, Fc) is 522 a.a., with molecular weight of ~96.6 kDa.
EphB2 protein is a receptor tyrosine kinase that participates in bidirectional signaling with the transmembrane ephrin B ligand. It guides commissural axons in the developing cerebral cortex, efferent growth cones of the inner ear, and retinal ganglion cell axons. EphB2 Protein, Human (HEK293, His) is the recombinant human-derived EphB2 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphB2 Protein, Human (HEK293, His) is 525 a.a., with molecular weight of 70-75 kDa.
The EphB1 protein is a receptor tyrosine kinase that promiscuously binds to the transmembrane ephrin-B ligand of adjacent cells, initiating bidirectional signaling. The forward signal originates from the receptor and the reverse signal originates from the ephrin ligand. EphB1 Protein, Human (540a.a, HEK293, His) is the recombinant human-derived EphB1 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphB1 Protein, Human (540a.a, HEK293, His) is 540 a.a., with molecular weight of ~60 kDa.
EphB2 protein is a receptor tyrosine kinase that participates in bidirectional signaling with the transmembrane ephrin B ligand. It guides commissural axons in the developing cerebral cortex, efferent growth cones of the inner ear, and retinal ganglion cell axons. EphB2 Protein, Human (sf9, His-GST) is the recombinant human-derived EphB2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of EphB2 Protein, Human (sf9, His-GST) is 418 a.a., with molecular weight of ~65 kDa.
EphB2 protein is a receptor tyrosine kinase that participates in bidirectional signaling with the transmembrane ephrin B ligand. It guides commissural axons in the developing cerebral cortex, efferent growth cones of the inner ear, and retinal ganglion cell axons. EphB2 Protein, Human (HEK293, His-Fc) is the recombinant human-derived EphB2 protein, expressed by HEK293 , with C-hFc, C-8*His labeled tag. The total length of EphB2 Protein, Human (HEK293, His-Fc) is 525 a.a., with molecular weight of approximately 95 kDa.
Ephrin-B1/EFNB1 Protein, a transmembrane ligand, interacts with Eph receptors, facilitating bidirectional signaling. It binds EPHB1/ELK and EPHB2/3, inducing axon collapse and growth cone orientation. EFNB1 also interacts with GRIP1/2, TLE1, and enhances ZHX2's transcriptional repression activity. These interactions highlight EFNB1's role in diverse developmental processes. Ephrin-B1/EFNB1 Protein, Human (HEK293, His) is the recombinant human-derived Ephrin-B1/EFNB1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Ephrin-B1/EFNB1 Protein, Human (HEK293, His) is 205 a.a., with molecular weight of ~34.0 kDa.
Ephrin-A4/EFNA4 proteins are cell surface GPI-binding ligands of Eph receptors that serve as critical mediators in a variety of cellular processes critical for migration, repulsion, and adhesion during neuronal, vascular, and epithelial development. As a promiscuous binder, Ephrin-A4 binds to Eph receptors on neighboring cells, stimulating contact-dependent bidirectional signaling to neighboring cells. Ephrin-A4/EFNA4 Protein, Mouse (150a.a, HEK293, Fc) is the recombinant mouse-derived Ephrin-A4/EFNA4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Ephrin-A4/EFNA4 Protein, Mouse (150a.a, HEK293, Fc) is 150 a.a., with molecular weight of ~53.0 kDa.
The EphA4 protein is a receptor tyrosine kinase that participates in contact-dependent bidirectional signaling with ephrin A and ephrin B ligands. EphA4 is activated by GPI-anchored EFNA and transmembrane EFNB and regulates cell morphology, integrin-dependent adhesion, and GTPase activity. EphA4 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived EphA4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EphA4 Protein, Mouse (HEK293, Fc) is 528 a.a., with molecular weight of ~110 kDa.
EphA4 Protein, a receptor tyrosine kinase, engages in contact-dependent bidirectional signaling with ephrin-A and ephrin-B ligands. Activated by GPI-anchored EFNA and transmembrane EFNB, EphA4 regulates cell morphology, integrin-dependent adhesion, and GTPase activity. Crucial in nervous system development, it guides axonal projections, segregates motor and sensory axons, and influences synaptic plasticity. In injury repair and angiogenesis, EphA4 inhibits axonal regeneration and contributes to vascular formation. Its promiscuity extends to thymic epithelium development, cochlear organ of Corti formation, and phosphorylation of CAPRIN1 for membraneless compartment formation. EphA4 Protein, Rat (HEK293, His) is the recombinant rat-derived EphA4 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphA4 Protein, Rat (HEK293, His) is 528 a.a., with molecular weight of ~70-80 kDa.
EphA4 Protein, a receptor tyrosine kinase, engages in contact-dependent bidirectional signaling with ephrin-A and ephrin-B ligands. Activated by GPI-anchored EFNA and transmembrane EFNB, EphA4 regulates cell morphology, integrin-dependent adhesion, and GTPase activity. Crucial in nervous system development, it guides axonal projections, segregates motor and sensory axons, and influences synaptic plasticity. In injury repair and angiogenesis, EphA4 inhibits axonal regeneration and contributes to vascular formation. Its promiscuity extends to thymic epithelium development, cochlear organ of Corti formation, and phosphorylation of CAPRIN1 for membraneless compartment formation. EphA4 Protein, Rat (HEK293, Fc) is the recombinant rat-derived EphA4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EphA4 Protein, Rat (HEK293, Fc) is 547 a.a., with molecular weight of ~98 kDa.
The EphA3 protein is a receptor tyrosine kinase that promiscuously binds to membrane-bound ephrin ligands to initiate bidirectional signaling. Activation of EphA3 is known to preferentially bind to EFNA5 and regulates cell-cell adhesion, cytoskeletal organization, and migration. EphA3 Protein, Mouse (sf9) is the recombinant mouse-derived EphA3 protein, expressed by Sf9 insect cells , with tag free. The total length of EphA3 Protein, Mouse (sf9) is 416 a.a., with molecular weight of ~44 kDa.
Ephrin-A4/EFNA4 Protein, a GPI-bound ligand, interacts with Eph receptors, crucial for neuronal, vascular, and epithelial development. It enables migration, repulsion, and adhesion by binding to neighboring Eph receptors, initiating bidirectional signaling. Furthermore, it potentially facilitates the interaction between activated B-lymphocytes and dendritic cells in tonsils. Ephrin-A4/EFNA4 Protein, Human (HEK293, His) is the recombinant human-derived Ephrin-A4/EFNA4 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Ephrin-A4/EFNA4 Protein, Human (HEK293, His) is 146 a.a., with molecular weight of ~20.0 kDa.
The EphA4 protein is a receptor tyrosine kinase that participates in bidirectional signaling with membrane-bound ephrin ligands including EFNA1 and EFNB3. EphA4 is activated by GPI-anchored ephrin A and transmembrane ephrin B and regulates cell morphology and integrin-dependent adhesion through regulation of Rac, Rap, and Rho GTPases. EphA4 Protein, Human (sf9, His-GST) is the recombinant human-derived EphA4 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of EphA4 Protein, Human (sf9, His-GST) is 417 a.a., with molecular weight of ~67 kDa.
The EphA4 protein is a receptor tyrosine kinase that participates in bidirectional signaling with membrane-bound ephrin ligands including EFNA1 and EFNB3. EphA4 is activated by GPI-anchored ephrin A and transmembrane ephrin B and regulates cell morphology and integrin-dependent adhesion through regulation of Rac, Rap, and Rho GTPases. EphA4 Protein, Human (HEK293, His-Fc) is the recombinant human-derived EphA4 protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of EphA4 Protein, Human (HEK293, His-Fc) is 547 a.a., with molecular weight of 100-110 kDa.
The EphA3 protein is a receptor tyrosine kinase that promiscuously binds to membrane-bound ephrin ligands to initiate bidirectional signaling. Activation of EphA3 is known to preferentially bind to EFNA5 and regulates cell-cell adhesion, cytoskeletal organization, and migration. EphA3 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived EphA3 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EphA3 Protein, Mouse (HEK293, Fc) is 541 a.a., with molecular weight of ~96 kDa.
The EphA3 protein is a receptor tyrosine kinase that promiscuously binds to membrane-bound ephrin ligands to initiate bidirectional signaling. Activation of EphA3 is known to preferentially bind to EFNA5 and regulates cell-cell adhesion, cytoskeletal organization, and migration. EphA3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived EphA3 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphA3 Protein, Mouse (HEK293, His) is 541 a.a., with molecular weight of ~60.2 kDa.
The EphA3 protein is a receptor tyrosine kinase that promiscuously binds to membrane-bound ephrin ligands to initiate bidirectional signaling. Activation of EphA3 is known to preferentially bind to EFNA5 and regulates cell-cell adhesion, cytoskeletal organization, and migration. EphA3 Protein, Rat (HEK293, Fc) is the recombinant rat-derived EphA3 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EphA3 Protein, Rat (HEK293, Fc) is 541 a.a., with molecular weight of ~103 kDa.
The EphA3 protein is a receptor tyrosine kinase that promiscuously binds to membrane-bound ephrin ligands to initiate bidirectional signaling. Activation of EphA3 is known to preferentially bind to EFNA5 and regulates cell-cell adhesion, cytoskeletal organization, and migration. EphA3 Protein, Rat (HEK293, His) is the recombinant rat-derived EphA3 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphA3 Protein, Rat (HEK293, His) is 521 a.a., with molecular weight of ~75-95 kDa.
The EphA4 protein is a receptor tyrosine kinase that participates in contact-dependent bidirectional signaling with ephrin A and ephrin B ligands. EphA4 is activated by GPI-anchored EFNA and transmembrane EFNB and regulates cell morphology, integrin-dependent adhesion, and GTPase activity. EphA4 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived EphA4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EphA4 Protein, Rhesus Macaque (HEK293, Fc) is 547 a.a., with molecular weight of ~85.4 KDa.
The EphA4 protein is a receptor tyrosine kinase that participates in contact-dependent bidirectional signaling with ephrin A and ephrin B ligands. EphA4 is activated by GPI-anchored EFNA and transmembrane EFNB and regulates cell morphology, integrin-dependent adhesion, and GTPase activity. EphA4 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived EphA4 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphA4 Protein, Rhesus Macaque (HEK293, His) is 528 a.a., with molecular weight of ~59.8-80 KDa.
Ephrin-A5/EFNA5 Protein, a cell surface GPI-bound ligand, crucially interacts with Eph receptors, inducing bidirectional signaling and regulating adhesion, organization, and development in neurons, vasculature, and epithelium. It forms complexes with EPHA3, EPHA8, and ADAM10, impacting internalization and function, while also mediating communication in pancreatic islet cells and influencing brain development. Ephrin-A5/EFNA5 Protein, Human (HEK293, Fc) is the recombinant human-derived Ephrin-A5/EFNA5 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Ephrin-A5/EFNA5 Protein, Human (HEK293, Fc) is 183 a.a., with molecular weight of 55-60 kDa.
The EphA3 protein is a receptor tyrosine kinase that promiscuously binds to membrane-bound ephrin ligands to initiate bidirectional signaling. Activation of EphA3 is known to preferentially bind to EFNA5 and regulates cell-cell adhesion, cytoskeletal organization, and migration. EphA3 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived EphA3 protein, expressed by Sf9 insect cells , with N-GST, N-His labeled tag. The total length of EphA3 Protein, Mouse (sf9, His-GST) is 416 a.a., with molecular weight of ~66 kDa.
Ephrin-A5/EFNA5 protein is the GPI-binding ligand of Eph receptor and plays a crucial role in neuronal, vascular and epithelial development. It binds to nearby Eph receptors, initiating bidirectional signaling and regulating intercellular adhesion and cytoskeletal organization. Ephrin-A5/EFNA5 Protein, Mouse (186a.a, HEK293, His) is the recombinant mouse-derived Ephrin-A5/EFNA5 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Ephrin-A5/EFNA5 Protein, Mouse (186a.a, HEK293, His) is 186 a.a., with molecular weight of 25-28 kDa.
The EphA1 protein is a receptor tyrosine kinase that promiscuously binds to ephrin-A ligands on neighboring cells, initiating contact-dependent bidirectional signaling. The forward signal originates from the receptor and the reverse signal originates from the ephrin ligand. EphA1 Protein, Human (522a.a, HEK293, His) is the recombinant human-derived EphA1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of EphA1 Protein, Human (522a.a, HEK293, His) is 522 a.a., with molecular weight of 70-85 kDa.
Ephrin-B2/EFNB2 is a key transmembrane ligand of Eph receptors that coordinates migration, repulsion, and adhesion in developing neurons, blood vessels, and epithelia. It induces bidirectional signaling, binding to EPHA4, EPHA3 and EPHB4, which is critical for cardiac morphogenesis and angiogenesis. Ephrin-B2/EFNB2 Protein, Human (HEK293, His) is the recombinant human-derived Ephrin-B2/EFNB2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Ephrin-B2/EFNB2 Protein, Human (HEK293, His) is 202 a.a., with molecular weight of 30-40 kDa.
The EphA4 protein is a receptor tyrosine kinase that participates in bidirectional signaling with membrane-bound ephrin ligands including EFNA1 and EFNB3. EphA4 is activated by GPI-anchored ephrin A and transmembrane ephrin B and regulates cell morphology and integrin-dependent adhesion through regulation of Rac, Rap, and Rho GTPases. EphA4 Protein, Human (HEK293) is the recombinant human-derived EphA4 protein, expressed by HEK293 , with tag free. The total length of EphA4 Protein, Human (HEK293) is 528 a.a., with molecular weight of 60-80 kDa.
The EphA7 protein is a receptor tyrosine kinase that participates in bidirectional signaling with GPI-anchored ephrin A ligands (such as EFNA5). It affects brain development by regulating cell-cell adhesion and repulsion. EphA7 Protein, Rat (HEK293, Fc) is the recombinant rat-derived EphA7 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EphA7 Protein, Rat (HEK293, Fc) is 539 a.a., with molecular weight of ~58.9 KDa.
The EphA7 protein is a receptor tyrosine kinase that participates in bidirectional signaling with GPI-anchored ephrin A ligands (such as EFNA5). It affects brain development by regulating cell-cell adhesion and repulsion. EphA7 Protein, Rat (HEK293, His) is the recombinant rat-derived EphA7 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphA7 Protein, Rat (HEK293, His) is 512 a.a., with molecular weight of ~65-72 KDa.
Ephrin-B2/EFNB2 Protein is a transmembrane ligand for Eph receptors, mediating bidirectional signaling and binding to EPHA4, EPHA3, and EPHB4. It regulates cell adhesion, migration, heart morphogenesis, angiogenesis, and axon orientation. It also interacts with PDZRN3. Ephrin-B2/EFNB2 Protein, Mouse (HEK293, Fc-His) is the recombinant mouse-derived Ephrin-B2/EFNB2 protein, expressed by HEK293 , with C-hFc, C-6*His labeled tag. The total length of Ephrin-B2/EFNB2 Protein, Mouse (HEK293, Fc-His) is 199 a.a., with molecular weight of 65-80 kDa.
Ephrin-A3/EFNA3 Protein, a GPI-bound ligand, interacts with Eph receptors, playing a critical role in neuronal, vascular, and epithelial development. It binds adjacent Eph receptors, initiating bidirectional signaling. Ephrin-A3/EFNA3 also activates EPHA8, contributing to its regulatory functions in migration, repulsion, and adhesion. Ephrin-A3/EFNA3 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Ephrin-A3/EFNA3 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Ephrin-A3/EFNA3 Protein, Mouse (HEK293, Fc) is 184 a.a., with molecular weight of 61-70 kDa.
The EPHA8 protein is a receptor tyrosine kinase that promiscuously binds to the GPI-anchored ephrin-A ligand to initiate bidirectional signaling. It participates in forward and reverse signaling pathways and is phosphorylated by ligands such as EFNA2, EFNA3, and EFNA5. EphA8 Protein, Human (HEK293, His) is the recombinant human-derived EphA8 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of EphA8 Protein, Human (HEK293, His) is 512 a.a., with molecular weight of 65-80 kDa.
Ephrin-B1/EFNB1 proteins are cell surface ligands of Eph receptors that critically regulate migration, repulsion, and adhesion during neuronal, vascular, and epithelial development. Ephrin-B1/EFNB1 Protein, Mouse (HEK293, Fc-His) is the recombinant mouse-derived Ephrin-B1/EFNB1 protein, expressed by HEK293 , with C-hFc, C-6*His labeled tag. The total length of Ephrin-B1/EFNB1 Protein, Mouse (HEK293, Fc-His) is 200 a.a., with molecular weight of 58-80 kDa.
Ephrin-A3/EFNA3 proteins are cell surface GPI-binding ligands of Eph receptors and play a key role in regulating key cellular processes such as migration, repulsion, and adhesion during neuronal, vascular, and epithelial development. As a promiscuous binder, Ephrin-A3 binds to Eph receptors on neighboring cells, initiating contact-dependent bidirectional signaling to neighboring cells. Ephrin-A3/EFNA3 Protein, Human (HEK293, His) is the recombinant human-derived Ephrin-A3/EFNA3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Ephrin-A3/EFNA3 Protein, Human (HEK293, His) is 189 a.a., with molecular weight of ~36.0 kDa.
The EphA7 protein is a receptor tyrosine kinase that promiscuously binds to the GPI-anchored ephrin-A ligand to initiate bidirectional signaling. It participates in forward and reverse signaling pathways, uses EFNA5 as a functional ligand, regulates brain development and affects cell adhesion and repulsion. EphA7 Protein, Human (HEK293, His) is the recombinant human-derived EphA7 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of EphA7 Protein, Human (HEK293, His) is 529 a.a., with molecular weight of ~72.0 kDa.
The EphB1 protein is a receptor tyrosine kinase that promiscuously binds to the transmembrane ephrin-B ligand of adjacent cells, initiating bidirectional signaling. The forward signal originates from the receptor and the reverse signal originates from the ephrin ligand. EphB1 Protein, Human (HEK293, Fc) is the recombinant human-derived EphB1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EphB1 Protein, Human (HEK293, Fc) is 523 a.a., with molecular weight of 85-100 kDa.
Ephrin-A1/EFNA1 Protein is a member of the A-type ephrin family of cell surface proteins that function as ligands for the A-type Eph receptor tyrosine kinase family (EphA2). EFNA1 exerts its function largely through interactions with EphA2. EFNA1 exists in a soluble form as well as a glycophosphatidylinositol (GPI) membrane attached form. EFNA1 acts as a membrane-bound, GPI-anchored protein capable of mediating juxtacrine signalling and requiring membrane attachment or clustering/oligomerization. EFNA1 is a novel TNF-inducible protein. EFNA1 efficiently binds to the EphA8 receptor expressed in NIH3T3 fibroblasts. EFNA1 stimulates PI3K activity via direct interaction of EphA2 with the p85 subunit of PI3K. EFNA1 can both inhibit and stimulate oncogenesis, depending on the cellular context. Ephrin-A1/EFNA1 Protein, Human (AAH32698.1, HEK293, His) is the recombinant human-derived Ephrin-A1/EFNA1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Ephrin-A1/EFNA1 Protein, Human (AAH32698.1, HEK293, His) is 164 a.a., with molecular weight of 25-30 kDa.
The Ephrin-A1/EFNA1 protein is a GPI-binding ligand critical for migration, repulsion, and adhesion in developing neurons, blood vessels, and epithelia. It binds to nearby Eph receptors, initiating bidirectional signaling. Ephrin-A1/EFNA1 Protein, Mouse (HEK293, Fc-His) is the recombinant mouse-derived Ephrin-A1/EFNA1 protein, expressed by HEK293 , with C-hFc, C-6*His labeled tag. The total length of Ephrin-A1/EFNA1 Protein, Mouse (HEK293, Fc-His) is 164 a.a., with molecular weight of ~45-65 kDa.
Cyclophilin B/PPIB protein is a peptidyl prolyl cis-trans isomerase (PPIase) that catalyzes the cis-trans isomerization of proline imide peptide bonds and may contribute to protein folding. This important enzymatic role highlights its importance in ensuring appropriate conformational changes in polypeptide chains, which are critical for functional maturation. Cyclophilin B/PPIB Protein, Human (HEK293, His) is the recombinant human-derived Cyclophilin B/PPIB protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Cyclophilin B/PPIB Protein, Human (HEK293, His) is 179 a.a., with molecular weight of ~19 kDa.
